The number of chronically undernourished people in the world remains unchanged since the World Food Summit in 1996: a total of 826 million people in both developing and industrialized countries. Moreover, as a result of the expansion of global urban population, more food needs to be produced, moved to cities and distributed; insufficient food supply and inefficient food distribution systems will result in higher food prices. The global demand for more food results in the globalization of the food supply, increasing the risk of spreading food-borne diseases across international borders. Recent stories about tainted strawberries, infected chickens, mad cow disease, for instance, have increased public concern on the need of a safe food supply. By the end of this course, the students should be able to understand the causes and current character of food insecurity, the essentials of food safety, factors affecting global food supply, and the effects of biotechnology on a secure and safe food supply.