Physicochemical Principles of Drug Action

To have an understanding of how the physical and chemical properties of drug molecules affect biological activity. Major topics: Nomenclature of simple organic dry molecules. Nomenclature and properties of common heterocyclic systems. The impact of functional groups on physicochemical properties and drug-receptor interaction of drug molecules. Physicochemical properties of drugs that influence pharmacological activity and pharmaceutical properties (e.g. acidity/basicity, hydrophobicity, electronic and steric effects). Energetics and stereochemical considerations in drug action. Chemical reactivity and basic metabolic transformations of drugs. Introduction to Quantitative Structure Activity Relationship (QSAR) studies. Target student: Pharmacy Year One.

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