Pharmaceutical Biotechnology

Learning objectives: To understand the various techniques in biotechnology and their applications in the manufacturing of biopharmaceuticals and biomedical research. To gain knowledge in some of the physicochemical properties, pharmacology and the formulation of commonly used biopharmaceuticals. To understand the principles of the mechanism of some biotechnologically drived diagnostic aids / tests.Major topics: Physicochemical properties, structure and stability of peptides & proteins. DNA sequencing by Maxam-Gilbert and Sanger's methods. Gene expression and its regulation. Principles of recombinant DNA technology & applications in medicine and research. Principles of site directed mutagenesis & applications in improving properties of proteins. Gene therapy, methods of gene delivery & applications in medicine. Hybridoma technology & applications in the production of monoclonal antibodies. Biotechnologically derived therapeutic proteins: insulin, human growth hormones, cytokines, enzymes, monoclonal antibodies, vaccines, blood products. Formulation and downstream processing of biopharmaceuticals. Dispensing biotechnology products. Diagnostic aids/tests for urine analysis, plasma glucose, plasma lipids, HIV, pregnancy and ovulationTarget students: Pharmacy Year Three

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